Effect of Diethylcarbamazine (DEC) on prostaglandin levels in Wuchereria bancrofti infected microfilaraemics.
Identifieur interne : 003691 ( Main/Exploration ); précédent : 003690; suivant : 003692Effect of Diethylcarbamazine (DEC) on prostaglandin levels in Wuchereria bancrofti infected microfilaraemics.
Auteurs : T. Sankari [Inde] ; S L Hoti ; L K Das ; V. Govindaraj ; P K DasSource :
- Parasitology research [ 1432-1955 ] ; 2013.
Descripteurs français
- KwdFr :
- 6-Cétoprostaglandine Fl alpha (sang), Animaux, Dinoprostone (sang), Diéthylcarbamazine (administration et posologie), Filaricides (administration et posologie), Filariose lymphatique (parasitologie), Filariose lymphatique (traitement médicamenteux), Humains, Parasitémie, Wuchereria bancrofti (isolement et purification).
- MESH :
- administration et posologie : Diéthylcarbamazine, Filaricides.
- isolement et purification : Wuchereria bancrofti.
- parasitologie : Filariose lymphatique.
- sang : 6-Cétoprostaglandine Fl alpha, Dinoprostone.
- traitement médicamenteux : Filariose lymphatique.
- Animaux, Humains, Parasitémie.
English descriptors
- KwdEn :
- 6-Ketoprostaglandin F1 alpha (blood), Animals, Diethylcarbamazine (administration & dosage), Dinoprostone (blood), Elephantiasis, Filarial (drug therapy), Elephantiasis, Filarial (parasitology), Filaricides (administration & dosage), Humans, Parasitemia, Wuchereria bancrofti (isolation & purification).
- MESH :
- chemical , administration & dosage : Diethylcarbamazine, Filaricides.
- chemical , blood : 6-Ketoprostaglandin F1 alpha, Dinoprostone.
- drug therapy : Elephantiasis, Filarial.
- isolation & purification : Wuchereria bancrofti.
- parasitology : Elephantiasis, Filarial.
- Animals, Humans, Parasitemia.
Abstract
Diethylcarbamazine (DEC) interferes with arachidonic acid metabolism for the clearance of microfilariae in Wuchereria bancrofti infected individuals. In this study, we have quantified the plasma concentrations of prostaglandin E2 (PGE2) and 6-keto-PGF1α, the end products of arachidonic acid metabolic pathway in microfilaraemics (DEC treated and untreated), and normal healthy individuals at pre- and 3,9,12,36, and 72 h of post-DEC treatment. We have also determined the microfilariae counts at pre and post day 2 (36 h) and day 3 (72 h) of DEC treatment by membrane filtration technique. Significant reduction in PGE2 and 6-keto-PGF1α concentrations was found at 12 h of DEC treatment. Rapid reduction in microfilarial counts was observed at 36 h of post-DEC treatment. Higher levels of prostaglandins were found at pre-treatment hours in microfilaraemics compared to normal healthy individuals (P < 0.05). Our findings indicate that DEC inhibits prostaglandins for the clearance of microfilariae, and increased levels of prostaglandins in microfilaraemics may be contributed by the parasite or host upon stimulation.
DOI: 10.1007/s00436-013-3399-y
PubMed: 23525692
Affiliations:
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Sankari</name><affiliation wicri:level="1"><nlm:affiliation>Molecular biology and Microbiology, Vector Control Research Centre (ICMR), Indira Nagar, Medical Complex, Pondicherry, 605 006, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Molecular biology and Microbiology, Vector Control Research Centre (ICMR), Indira Nagar, Medical Complex, Pondicherry, 605 006</wicri:regionArea><wicri:noRegion>605 006</wicri:noRegion></affiliation></author><author><name sortKey="Hoti, S L" sort="Hoti, S L" uniqKey="Hoti S" first="S L" last="Hoti">S L Hoti</name></author><author><name sortKey="Das, L K" sort="Das, L K" uniqKey="Das L" first="L K" last="Das">L K Das</name></author><author><name sortKey="Govindaraj, V" sort="Govindaraj, V" uniqKey="Govindaraj V" first="V" last="Govindaraj">V. 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Sankari</name><affiliation wicri:level="1"><nlm:affiliation>Molecular biology and Microbiology, Vector Control Research Centre (ICMR), Indira Nagar, Medical Complex, Pondicherry, 605 006, India.</nlm:affiliation><country xml:lang="fr">Inde</country><wicri:regionArea>Molecular biology and Microbiology, Vector Control Research Centre (ICMR), Indira Nagar, Medical Complex, Pondicherry, 605 006</wicri:regionArea><wicri:noRegion>605 006</wicri:noRegion></affiliation></author><author><name sortKey="Hoti, S L" sort="Hoti, S L" uniqKey="Hoti S" first="S L" last="Hoti">S L Hoti</name></author><author><name sortKey="Das, L K" sort="Das, L K" uniqKey="Das L" first="L K" last="Das">L K Das</name></author><author><name sortKey="Govindaraj, V" sort="Govindaraj, V" uniqKey="Govindaraj V" first="V" last="Govindaraj">V. Govindaraj</name></author><author><name sortKey="Das, P K" sort="Das, P K" uniqKey="Das P" first="P K" last="Das">P K Das</name></author></analytic><series><title level="j">Parasitology research</title><idno type="eISSN">1432-1955</idno><imprint><date when="2013" type="published">2013</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>6-Ketoprostaglandin F1 alpha (blood)</term><term>Animals</term><term>Diethylcarbamazine (administration & dosage)</term><term>Dinoprostone (blood)</term><term>Elephantiasis, Filarial (drug therapy)</term><term>Elephantiasis, Filarial (parasitology)</term><term>Filaricides (administration & dosage)</term><term>Humans</term><term>Parasitemia</term><term>Wuchereria bancrofti (isolation & purification)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>6-Cétoprostaglandine Fl alpha (sang)</term><term>Animaux</term><term>Dinoprostone (sang)</term><term>Diéthylcarbamazine (administration et posologie)</term><term>Filaricides (administration et posologie)</term><term>Filariose lymphatique (parasitologie)</term><term>Filariose lymphatique (traitement médicamenteux)</term><term>Humains</term><term>Parasitémie</term><term>Wuchereria bancrofti (isolement et purification)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Diethylcarbamazine</term><term>Filaricides</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>6-Ketoprostaglandin F1 alpha</term><term>Dinoprostone</term></keywords><keywords scheme="MESH" qualifier="administration et posologie" xml:lang="fr"><term>Diéthylcarbamazine</term><term>Filaricides</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="isolation & purification" xml:lang="en"><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="isolement et purification" xml:lang="fr"><term>Wuchereria bancrofti</term></keywords><keywords scheme="MESH" qualifier="parasitologie" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" qualifier="parasitology" xml:lang="en"><term>Elephantiasis, Filarial</term></keywords><keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>6-Cétoprostaglandine Fl alpha</term><term>Dinoprostone</term></keywords><keywords scheme="MESH" qualifier="traitement médicamenteux" xml:lang="fr"><term>Filariose lymphatique</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Humans</term><term>Parasitemia</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Animaux</term><term>Humains</term><term>Parasitémie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Diethylcarbamazine (DEC) interferes with arachidonic acid metabolism for the clearance of microfilariae in Wuchereria bancrofti infected individuals. In this study, we have quantified the plasma concentrations of prostaglandin E2 (PGE2) and 6-keto-PGF1α, the end products of arachidonic acid metabolic pathway in microfilaraemics (DEC treated and untreated), and normal healthy individuals at pre- and 3,9,12,36, and 72 h of post-DEC treatment. We have also determined the microfilariae counts at pre and post day 2 (36 h) and day 3 (72 h) of DEC treatment by membrane filtration technique. Significant reduction in PGE2 and 6-keto-PGF1α concentrations was found at 12 h of DEC treatment. Rapid reduction in microfilarial counts was observed at 36 h of post-DEC treatment. Higher levels of prostaglandins were found at pre-treatment hours in microfilaraemics compared to normal healthy individuals (P < 0.05). Our findings indicate that DEC inhibits prostaglandins for the clearance of microfilariae, and increased levels of prostaglandins in microfilaraemics may be contributed by the parasite or host upon stimulation.</div></front></TEI><affiliations><list><country><li>Inde</li></country></list><tree><noCountry><name sortKey="Das, L K" sort="Das, L K" uniqKey="Das L" first="L K" last="Das">L K Das</name><name sortKey="Das, P K" sort="Das, P K" uniqKey="Das P" first="P K" last="Das">P K Das</name><name sortKey="Govindaraj, V" sort="Govindaraj, V" uniqKey="Govindaraj V" first="V" last="Govindaraj">V. Govindaraj</name><name sortKey="Hoti, S L" sort="Hoti, S L" uniqKey="Hoti S" first="S L" last="Hoti">S L Hoti</name></noCountry><country name="Inde"><noRegion><name sortKey="Sankari, T" sort="Sankari, T" uniqKey="Sankari T" first="T" last="Sankari">T. Sankari</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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